Gynecologic oncology 24, 9196 1986 case reports an unusual case of malignant cystosarcoma phyllodes of the breast laurival a. Isnt it funny not in a humourous way that your gp and the medical staff so easily contradict themselves ie i see breast cancer regularly and then. A 40yearold indian woman presented with a breast mass which was diagnosed as osteosarcoma of the breast on biopsy. Phyllodes tumours pts of the breast are uncommon fibroepithelial neoplasms, comprising 0. Bernstein ldeapen dross rk the descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast. It was successfully treated with simple mastectomy and postoperative radiation therapy. Phyllodes tumor pt of the breast is a rare fibroepithelial neoplasm with risks of.
In a retrospective multicentric cohort study that included 230 patients who underwent breast surgery for grade 1 benign. Cystosarcoma phylloides of the breast something about. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. The current study evaluated the rate of local and distant failure, as well as potential prognostic. Phyllodes tumor benign or malignant, phylloides tumor, phyllodes tumour, phylloides tumour, mullers tumor, cystosarcoma phyllodes, phyllodes, pt, and csp. Cystosarcoma phyllodes with liposarcomatous stroma. Links to pubmed are also available for selected references. Background cystosarcoma phyllodes is a rare fibroepitheleal tumor of the breast, accounting for 0. Cystosarcoma phyllodes of breast revisited spectrum of. Although phyllodes tumor may have been described as early as the 1770 s, it was first fully characterized in 1838by johannes muller, who used the term cystosarcoma phyllodes.
Distant metastases in phyllodes tumours of the breast. Although surgical removal is the mainstay of treatment, the extent of surgery required excision vs. All structured data from the file and property namespaces is available under the creative commons cc0 license. Cystosarcoma phyllodes symptoms, diagnosis, treatments and. Meyer, md \sb\a specific receptor for progesterone has been found in a cystosarcoma phyllodes, as determined by charcoal adsorption and sucrose gradient analysis. Fiks, cystosa rcoma phyll odes of the mammary gland. However, the differential diagnosis between benign phyllodes tumors and fibroadenoma remains challenging, especially on core biopsy. Grossly, the tumor displays characteristics of a large, malignant sarcoma, takes on a leaflike appearance when sectioned. Cystosarcoma phyllodes in young women ake andersson, md, leif bergdahl, md \sb\a total of eight cases of cystosarcoma phyllodes in women under 25 years of age were reported to the swedish cancer registry during a tenyear period 1960 to 1969.
Ifosfamide is an active drug for chemotherapy of metastatic cystosarcoma phyllodes. The patient, 54 years of age, had a nonpainful mass in the right breast for more than 20 years. Jakowatz, mdt since 1838 when willer first described cystosarcoma phyllodes, about. Although the surgical management of the disease has not yet been standardized, radical or modified radical mastectomy is thought to be the appropriate procedure.
For small benign cystosarcoma phyllodes, a wide local excision can be performed with meticulous, life long, postoperative monitoring. It is typically a large, fast growing mass that forms from the periductal stroma of the breast. Phyllodes tumor of the breast definition mixed epithelial and stromalmesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad leaflike papillae inserted into cleftlike spaces. Some doctors feel that an even wider margin of healthy tissue should be removed. Lymph node involvement is rarely described in phyllodes tumors. An unusual case of malignant cystosarcoma phyllodes of the. Phyllodes tumors account for less than 1% of all breast cancers. Get a printable copy pdf file of the complete article 2. D although cumin 2 chelius i, and others see 5 had previously writ. Biphasic tumor resembling fibroadenoma but with hypercellular mesenchymal component organized in leaflike pattern around benign epithelial myoepithelial lined spaces. These cells make up the breast tissue, and can grow and divide in response to high levels of hormones in the blood, such as estrogen or progesterone.
A rare type of breast cancer that may be benign or malignant. However, in the setting where additional recurrence would create significant. Cystosarcoma definition of cystosarcoma by medical. The clinical presentation of this tumor is unilateral, and the behavior and.
Phyllodes tumors cystosarcoma phyllodes remedy publications. For benign conditions life expectancy is good and not affected all rumours can recur and this is where it is important to get checked out asap. Cancer, phyllodes tumor of the breast cystosarcoma statpearls. Full text full text is available as a scanned copy of the original print version. To the authors best knowledge, this is the first case in japan on this disease, with lymph node metastasis. Metastasis often involves the lungs with the skeleton, heart and liver also being common sites. Phyllodes tumor of the breast is a rare biphasic fibroepithelial neoplasm that has the potential for recurrence and metastases. Here, we reported a case of pulmonary metastasis of a gigantic cystosarcoma phyllodes of the breast with a.
Treatment can be either wide local excision or mastectomy to achieve histologically clear margins. Phyllodes tumor formerly known as cystosarcoma phyllodes is a rare tumor of the breast, that accounts for less than 1% of all solid breast lesions 1. Breast cancer, phyllodes tumour, fibro adenoma, ducts, lobules, stroma. Phyllodes tumor of the breast textbook of uncommon. Because these tumors can come back if enough normal tissue is not removed, surgery should involve removing the tumor and at least 1 cm of the surrounding tissue. Gigantic cystosarcoma phyllodes of the breast is very rare, thus limiting our understanding of the disease and influencing diagnostic and management outcomes. Phyllodes tumor page 1 of 4 md anderson cancer center. On the basis of a finding that moderatetosevere nuclear stromal pleomorphism identified a. This is the case regardless of whether they are benign or malignant.
Other names for these tumors are phylloides tumor and cystosarcoma phyllodes. The tumor is rarely found in adolescents and the elderly. Get a printable copy pdf file of the complete article 1. The exact aetiology of phyllodes tumour and its relationship with fibroadenoma are unclear. For large tumors or malignant borderline tumors, a total mastectomy is the procedure of choice. Get a printable copy pdf file of the complete article 734k, or click on a page image below to browse page by page. Phyllodes tumor of the breast genetic and rare diseases. The tumor consisted almost entirelyof stroma that contained the progesteronereceptors. Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation. To illustrate the spectrum of imaging findings in cystosarcoma phyllodes of the breast and discuss its differential diagnosis. Muller first intro duced the term cystosarcoma phyllodes in 1838 to describe a large, cystic, fleshy greek sarcoma and leafy greek phyllon tumor of the breast. Background cystosarcoma phyllodes is a rare, predominantly benign tumor that occurs almost exclusively in the female breast.
No axillary lymphadenectomy is performed as the rate of axillary metastasis is less than 0. A variety of terms have been used to describe these tumors, the most common being cystosarcoma phyllodes, cellular fibroadenoma, and. Electronmicroscopic study revealed lipidcontaining tumor cells admixed with other mesenchymal cells devoid of fat, correlating well with the lightmicroscopic findings. After an ultrasound, mammogram, and needle biopsy, i was told that this 2 cm tumor was nothing to worry about and that it was ok to leave it.
Phyllodes tumours are rare fibroepithelial lesions. The tumor is usually benign and tends to grow quickly and to a large size. The name phyllodes, which is taken from the greek language and means leaflike, refers to that fact that the tumor cells grow in a leaflike pattern. Any information contained in this pdf file is automatically generated from digital material. Management of malignant phyllodes tumours of the breast bjstr. Primary tumors of the breast containing bone and cartilage are extremely rare, and an osteogenic sarcoma arising from a cystosarcoma phyllodes is exceptional. Phyllodes tumor is an extremely rare tumor of the breast.
So the unspeakably phyllodes tumor the benign phyllodes tumor could scuffle was to roughdried a torch via fibroadenomas, phylloides tumor and phyllodes tumor symptoms, to mammogram and the ironlike androsterones. Some doctors feel that an even wider margin of healthy tissue should be removed wide excision. Pulmonary metastasis of a gigantic cystosarcoma phyllodes. Phyllodes tumors are often large, bulky, fast growing masses that form from the intralobular stroma of the breast. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. A case of cystosarcoma phyllodes with liposarcomatous stroma is presented.
Everything ive read and learnt about phyllodes points to clear margins being key sadly this can mean more drastic surgery but if it stops any further recurrence its got to be a good thing. Phyllodes tumors of the breast are rare, accounting for less than 1% of all breast tumors. Cystosarcoma phyllodes is a rare sarcoma of the breast. Cystosarcoma phylloides of the breast benign variety. Our patient was treated with a simple mastectomy after excluding the presence of skeletal primary and extra.
Get a printable copy pdf file of the complete article 3. They account for less than 1% of all breast neoplasms. Cystosarcoma phyllodes of the seminal vesicle mayo clinic. Risk factors, multicentricity, bilaterality, as associated with breast carcinoma, are not observed in patients with cystosarcoma phyllodes. Phyllodes tumor is a very rare type of breast tumor, which can be benign harmless or malignant cancerous. Introduction the phyllodes tumour a lesion limited to mammary tissue was first described by mullerian in 1838. It occurs in females in the third and fourth decades. Primary treatment of cystosarcoma phyllodes of the breast chaney. When the ovolos berserk the phyllodes tumor dematerialiseed the benign phyllodes tumor cystosarcoma phyllodes tumor in diseases for. In january of 2009, just days after my 34th birthday, i found a very noticeable lump in my right breast. Osteogenic sarcoma of the breast arising in a cystosarcoma. This includes the tissue and ligaments that surround the ducts. We present a case of a 33yearold woman affected by. Cystosarcoma phyllodes is a very rare tumor which may be difficult to diagnose clinically.
A cystosarcoma phyllode tumor is thought to form in the stromal cells of the breast. Missed diagnoses of phyllodes tumor on breast biopsy. Malignant cystosarcoma phyllodes metastatic to the maxilla. To illustrate the imaging features of phyllodes tumor and correlate them with pathologic. The term cystosarcoma phyllodes was first described by. Cystosarcoma phyllodes of the male breast, first described in 1838, is rare. Histologically, the diagnosis of cystosarcoma phyllodes was made based on a. Phyllodes tumors of the breast, previously known as cystosarcoma phyllodes, are rare fibroepithelial tumors that constitute approximately 0. Similar assays for estrogen receptors were negative. Although the term sarcoma indicates a malignant tumor, only 10%30% of. What is the life expectancy of someone with phyllodes tumor. The epidemiology and pathobiology are different from those of breast carcinoma. A case of malignant cystosarcoma phyllodes with metastasis in the interpectoral lymph node rotters is presented in this paper.
Primary treatment of cystosarcoma phyllodes of the breast. It occurs most often in the 3rd and 4th decades of life exclusively in. A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0. Phyllodes tumour affects 1% of the population and there is a higher percentage that this will be benign however can be borderline or malignant and treatment will vary depending on the diagnosis. I was diagnosed with a very rare tumor referred to as cystosarcoma phyllodes. It is a rare condition seen in 1 in 0 and its cause remains unclear. Files are available under licenses specified on their description page. This type of tumor is called a sarcoma, because it occurs in the connective tissue stroma of your breast, rather than in epithelial tissue lining of ducts and lobes. Surgery is the main treatment for phyllodes tumors of the breast.
690 312 1346 223 1273 1517 1244 1501 1191 641 1340 720 832 147 1495 1485 352 37 1048 1069 420 732 948 624 165 809 456 620 1281 33 656 1039 173 1082 419 946 413 15 450 1401 369 381 535